In League of Legends Wild Rift Vayne is a Marksman that highly play in Dragon lane. View Vayne Best builds, Runes, Matchups, and more here!
Vayne Build Guide
Full Build
 Blade of the Ruined King |  Gluttonous Greaves |  Phantom Dancer | 
 Infinity Edge |  Rapid Firecannon |  Guardian Angel | 
In Wild Rift Vayne build items that increase Physical damage, Attack speed, and Critical rate so she can be the main attack damage carry (ADC) of the team.
Enchantment: 
 Quicksilver is an item that Ashe should build.
Core Items
 Blade of the Ruined King |  Gluttonous Greaves |  Phantom Dancer | 
Vayne core items are Blade of the Ruined King, Gluttonous Greaves, Phantom Dancer.
The core items increase Attack damage, Attack speed, Physical vamp, Critical rate and shield.
Other Options
 Statikk Shiv |  Bloodthirster |  Maw of Malmortius | 
 Mortal Reminder |  Frozen Mallet |  Stasis Enchant | 
Down below are different techniques to build on Vayne against different enemy match up.
Build Vs Fighter
 Blade of the Ruined King |  Gluttonous Greaves |  Phantom Dancer | 
 Infinity Edge |  Bloodthirster |  Frozen Mallet | 
Build 
 Bloodthirster to get physical vamp and shield when you have full health.
Build 
 Frozen Mallet to apply slow to the enemy when attack, and extra health.
Build Vs Assassin
 Blade of the Ruined King |  Gluttonous Greaves |  Phantom Dancer | 
 Infinity Edge |  Bloodthirster |  Guardian Angel | 
Build 
 Guardian Angel to survive high damage burst by Assassin combo skills.
Build Vs Mage
 Blade of the Ruined King |  Gluttonous Greaves |  Phantom Dancer | 
 Infinity Edge |  Maw of Malmortius |  Guardian Angel | 
Build 
 Maw of Malmortius to get magic resist and gain shield when health are below 35%.
Build 
 Guardian Angel to survive high damage burst by mage combo skills.
Build 
 Stasis Enchant to survive mage combo skills.
Build Vs Tank
 Blade of the Ruined King |  Gluttonous Greaves |  Phantom Dancer | 
 Infinity Edge |  Rapid Firecannon |  Mortal Reminder | 
Build 
 Mortal Reminder to get Armor penetration, and effectively attack tank champions.
Vayne Jungle
 Blade of the Ruined King |  Gluttonous Greaves |  Statikk Shiv | 
 Infinity Edge |  Phantom Dancer |  Mortal Reminder | 
Recommended build from in-game.
Vayne Runes
The best Wild Rift Vayne Runes are Fleet Footwork keystone, Gathering Storm, Spirit Walker, and Sweet tooth.
 Fleet Footwork | Moving, attacking and casting builds energy stacks. At maximum stacks, your next attack heals and grants increased movement speed. | 
 Gathering Storm | Every 2 minutes, gain AD or AP (Adaptive). | 
 Spirit Walker | Gain bonus max health and slow resistance. | 
 Sweet Tooth | Increased Honeyfruit healing effect, each fruit also provides bonus gold. | 
Summoner Spells
 Heal | Restores Health and grants bonus Movement Speed to you and the most wounded nearby ally champions. | 
 Flash | Teleport a short distance forward or towards the aim direction. | 
Vayne Abilities Guide
Skill Details
 Night Hunter | Gains 15 Movement Speed when moving towards enemy champions. Final Hour: Gains 90 Movement speed instead.  | 
 Tumble | Dashes forward and empowers her next attack to deal an additional physical damage. Final Hour: Gains 1 second of invisibility on cast. Cooldown : 3.5 / 3 / 2.5 / 2 / 2 Mana Cost: 30  | 
 Silver Bolts | Passive: Every third consecutive attack or ability on the same target deals additional true damage equal to 3% of the enemy maximum Health. Active: Gains 40% Attack Speed for the next 3 attacks within 5 seconds and heals for 60% of the damage from Silver Bolts dealt. Cooldown: 16 / 15 / 14 / 13 Mana Cost: 45  | 
 Condemn | Fires a bolt that deals 50 physical damage and knocks back. If enemies are knocked into a wall, they take an additional 75 physical damage and are stunned for 1.5 seconds. Cooldown: 18 / 16 / 14 /12 Mana Cost: 90  | 
 Final Hour | Gains 20 Attack Damage and strengthens Night Hunter and Tumble for 8 seconds. When an enemy champion damaged by Vayne dies within 3 seconds, Final Hour's duration is extended by 4 seconds, up to an additional 8 seconds. Cooldown: 100 / 80 / 60 Mana Cost: 100  | 
Skill Orders
 Tumble |  Silver Bolts |  Condemn |  Final Hour | 
| 1 | 2 | 3 | 5 | 
| 8 | 4 | 12 | 9 | 
| 10 | 6 | 14 | 13 | 
| 11 | 7 | 15 | 
Skill Combos
1. 
 Silver Bolts > 2x attack > 
 Tumble.
2. 
 Silver Bolts > 2x attack > 
 Condemn.
3. 
 Final Hour > 
 Tumble > 
 Silver Bolts > 
 Condemn.
4. 
 Final Hour > 
 Silver Bolts > 
 Tumble > 
 Condemn.
Vayne Matchups & Partners
Enemy Matchups
| Good Against | |
| Vayne  | |
| When playing Vayne vs Jinx you'll have more advantage over her during early game because of Jinx low attack damage, so try to harass her with  | |
| Picking Vayne against Varus is a good choice. You can use  | |
| When using Vayne vs Jhin you will have high advantage because Jhin has low attack speed in early game, you can win auto attack trade easily with  | |
| Vayne is a good pick to play against Tristana, Both of the champions has good attack damage and speed, but you can counter Tristana aggressive play by using  | |
| Hard Counters | |
Draven is the hardest Vayne counter in Wild Rift, this champion deal very high damage against Vayne in early game and can punish her with   | |
| MF is a great champion to counter Vayne, she has more range, great mobility and she can punish you by using ability like  | |
| Ezreal is a good Vayne counter pick by having higher  | |
| Picking Vayne to play against Kai'Sa is always hard since she can outclass you during team fight with her  | |
Support Partners
| The best synergies for Vayne is Braum, his  | |
| Blitzcrank is a great aggresive support to use with Vayne as well. His  | |
| Alisatar is a good aggressive support to play with Vayne, If Alistar can do a  | |
| LuLu and Vayne is a powerful synergies. LuLu can provide shield on Vayne by using  | |
| Seraphine is a healing and aggressive support champion that can play well with Vayne, she can  | |
| Nami and Vayne is a good synergies, she can heal you with her  | |
| Soraka is a great healer support that can play with Vayne, she can heal you with her  | |
| Sona is a good healer and aggressive support champion that can lane well with Vayne, she can  | |
| Janna is a decent support to use with Vayne, she is a great defensive support that can provide  | 
Vayne Pros and Cons
| Pros | 
| 1. One of the highest burst damage champion. | 
| 2. Has great mobility to get in and out of team fight. | 
| 3. Has ability to disengage and stunt the enemy from target her. | 
| 4. Powerful Ultimate allows her to engage in team fight without fully notice by enemy. | 
| Cons | 
| 1. Has low Base HP and Armor. | 
| 2. Can easily get punish when losing lane. | 
| 3. Vayne is difficult to master. | 

Blade of the Ruined King
Gluttonous Greaves
Phantom Dancer
Infinity Edge
Rapid Firecannon
Guardian Angel
Statikk Shiv
Bloodthirster
Maw of Malmortius
Mortal Reminder
Frozen Mallet
Stasis Enchant
Fleet Footwork
Gathering Storm
Spirit Walker
Sweet Tooth
Heal
Flash
Night Hunter
Tumble
Silver Bolts
Condemn
Final Hour